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Target
D(2) dopamine receptor
Ligand
BDBM312188
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
0.61±0.0 nM
IC50
1.96±0.0 nM
Citation
 Bhat, L; Mohapatra, PP; Adiey, K Arylpiperazine derivatives and methods of utilizing same US Patent  US9604944 Publication Date 3/28/2017 
Target
Name:
D(2) dopamine receptor
Synonyms:
D2(Short) | Dopamine D2 S receptor
Type:
n/a
Mol. Mass.:
47370.77
Organism:
Homo sapiens (Human)
Description:
P14416-2
Residue:
414
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM312188
Synonyms:
6-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butoxy)-2H-benzo[b][1,4]oxazin-3(4H)-one | US10441590, Compound B | US9604944, 15b (Example 14) | US9975862, 15b (Example 14)
Type:
Small organic molecule
Emp. Form.:
C22H25Cl2N3O3
Mol. Mass.:
450.358
SMILES:
Clc1cccc(N2CCN(CCCCOc3ccc4OCC(=O)Nc4c3)CC2)c1Cl
Structure:
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