Reaction Details Report a problem with these data
Target
Nicotinamide phosphoribosyltransferase
Ligand
BDBM180055
Substrate
n/a
Meas. Tech.
Biochemical Inhibition Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
6.50±n/a nM
Comments
extracted
Citation
 Bair, KW; Buckmelter, AJ; Han, B; Lin, J; Reynolds, DJ; Smith, CC; Wang, Z; Zheng, X Compounds and compositions for the inhibition of NAMPT US Patent  US9676721 Publication Date 6/13/2017 
Target
Name:
Nicotinamide phosphoribosyltransferase
Synonyms:
NAMPT | NAMPT_HUMAN | NAmPRTase | Nicotinamide phosphoribosyltransferase | Nicotinamide phosphoribosyltransferase (NAMPT) | PBEF | PBEF1 | Pre-B-cell colony-enhancing factor 1
Type:
Enzyme
Mol. Mass.:
55524.98
Organism:
Homo sapiens (Human)
Description:
P43490
Residue:
491
Sequence:
MNPAAEAEFNILLATDSYKVTHYKQYPPNTSKVYSYFECREKKTENSKLRKVKYEETVFYGLQYILNKYLKGKVVTKEKIQEAKDVYKEHFQDDVFNEKGWNYILEKYDGHLPIEIKAVPEGFVIPRGNVLFTVENTDPECYWLTNWIETILVQSWYPITVATNSREQKKILAKYLLETSGNLDGLEYKLHDFGYRGVSSQETAGIGASAHLVNFKGTDTVAGLALIKKYYGTKDPVPGYSVPAAEHSTITAWGKDHEKDAFEHIVTQFSSVPVSVVSDSYDIYNACEKIWGEDLRHLIVSRSTQAPLIIRPDSGNPLDTVLKVLEILGKKFPVTENSKGYKLLPPYLRVIQGDGVDINTLQEIVEGMKQKMWSIENIAFGSGGGLLQKLTRDLLNCSFKCSYVVTNGLGINVFKDPVADPNKRSKKGRLSLHRTPAGNFVTLEEGKGDLEEYGQDLLHTVFKNGKVTKSYSFDEIRKNAQLNIELEAAHH
  
Inhibitor
Name:
BDBM180055
Synonyms:
US9676721, 112 5-[(4-{[2-cyano-3-(pyridin-4-yl)carbamimidamido]methyl}benzene)sulfonyl]-N-methylpyridine-2-carboxamide
Type:
Small organic molecule
Emp. Form.:
C21H20N7O3S
Mol. Mass.:
450.494
SMILES:
Cn1cc(ccc1C(N)=O)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Structure:
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