Reaction Details Report a problem with these data
Target
P2X purinoceptor 7
Ligand
BDBM267171
Substrate
n/a
Meas. Tech.
YO-PRO-1 Uptake Assay
IC50
42.0±n/a nM
Citation
 Pevarello, P; Lohmer, S; Llberati, C; Seneci, P; Pesenti, C; Prandi, A Substituted thiazole or oxazole P2X7 receptor antagonists US Patent  US10167281 Publication Date 1/1/2019 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor
Type:
Protein
Mol. Mass.:
68602.85
Organism:
Homo sapiens (Human)
Description:
Q99572
Residue:
595
Sequence:
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
  
Inhibitor
Name:
BDBM267171
Synonyms:
N-[2-(2-cyclobutyl-1,3-thiazol-5-yl)-2-(4,4-difluoropiperidin-1-yl)ethyl]-2-fluoro-5-(5-fluoropyrimidin-2-yl)benzamide | US10167281, Compound 106 | US9718812, 106
Type:
Small organic molecule
Emp. Form.:
C25H25F4N5OS
Mol. Mass.:
519.558
SMILES:
Fc1cnc(nc1)-c1ccc(F)c(c1)C(=O)NCC(N1CCC(F)(F)CC1)c1cnc(s1)C1CCC1
Structure:
Search PDB for entries with ligand similarity: