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Target
P2X purinoceptor 7
Ligand
BDBM267184
Substrate
n/a
Meas. Tech.
YO-PRO-1 Uptake Assay
IC50
36.0±n/a nM
Citation
 Pevarello, P; Lohmer, S; Llberati, C; Seneci, P; Pesenti, C; Prandi, A Substituted thiazole or oxazole P2X7 receptor antagonists US Patent  US10167281 Publication Date 1/1/2019 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2RX7 | P2RX7_HUMAN | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor
Type:
Protein
Mol. Mass.:
68602.85
Organism:
Homo sapiens (Human)
Description:
Q99572
Residue:
595
Sequence:
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
  
Inhibitor
Name:
BDBM267184
Synonyms:
2-chloro-N-[2-(4,4-difluoropiperidin-1-yl)-2-[2-(hydroxymethyl)-1,3-thiazol-5-yl]ethyl]-5-(5-fluoropyrimidin-2- | US10167281, Compound 112 | US9718812, 112
Type:
Small organic molecule
Emp. Form.:
C22H21ClF3N5O2S
Mol. Mass.:
511.948
SMILES:
OCc1ncc(s1)C(CNC(=O)c1cc(ccc1Cl)-c1ncc(F)cn1)N1CCC(F)(F)CC1
Structure:
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