Reaction Details Report a problem with these data
Target
Amine oxidase [flavin-containing] B
Ligand
BDBM10729
Substrate
BDBM10758
Meas. Tech.
Cholinesterase Inhibition Assay
IC50
>1000000±n/a nM
Citation
Sterling, J; Herzig, Y; Goren, T; Finkelstein, N; Lerner, D; Goldenberg, W; Miskolczi, I; Molnar, S; Rantal, F; Tamas, T; Toth, G; Zagyva, A; Zekany, A; Finberg, J; Lavian, G; Gross, A; Friedman, R; Razin, M; Huang, W; Krais, B; Chorev, M; Youdim, MB; Weinstock, M Novel dual inhibitors of AChE and MAO derived from hydroxy aminoindan and phenethylamine as potential treatment for Alzheimer's disease. J Med Chem 45:5260-79 (2002) [PubMed] Article
More Info.:
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_RAT | Amine oxidase (flavin-containing) B | Amine oxidase [flavin-containing] B | Maob | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B (MAO-B) | Monoamine oxidase B (rMAO-B) | Monoamine oxidase type B (MAOB) | Monoamine oxidase-B (MAO-B)
Type:
Enzyme
Mol. Mass.:
58469.65
Organism:
Rattus norvegicus (rat)
Description:
P19643
Residue:
520
Sequence:
MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWRTMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQTGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVYYKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEERLRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGKIFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNTFLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
Inhibitor
Name:
BDBM10729
Synonyms:
3-amino-2,3-dihydro-1H-inden-5-yl N-methyl-N-propylcarbamate | Aminoindan deriv. 7c
Type:
Small organic molecule
Emp. Form.:
C14H20N2O2
Mol. Mass.:
248.3208
SMILES:
CCCN(C)C(=O)Oc1ccc2CCC(N)c2c1