Reaction Details Report a problem with these data
Target
Isocitrate dehydrogenase [NADP] cytoplasmic [1-390,401-414,R132C]
Ligand
BDBM317489
Substrate
n/a
IC50
>10000±n/a nM
Citation
Lin, J; Ericsson, A; Campbell, A; Gustafson, G; Wang, Z; Diebold, RB; Ashwell, S; Lancia, Jr., DR; Caravella, JA; Lu, W Fused-bicyclic aryl quinolinone derivatives as mutant-isocitrate dehydrogenase inhibitors US Patent US9624175 Publication Date 4/18/2017
More Info.:
Target
Name:
Isocitrate dehydrogenase [NADP] cytoplasmic [1-390,401-414,R132C]
Synonyms:
IDH1 | IDHC_HUMAN | Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)(R132C) | PICD
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45318.79
Organism:
Homo sapiens (Human)
Description:
O75874[1-390,401-414,R132C]
Residue:
404
Sequence:
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGCHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDLGENLKIKLAQAKL