Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM318435
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
IC50
55.9±n/a nM
Citation
 McCarthy, TD; Naylor, A Heterocyclic compounds and methods for their use US Patent  US9624234 Publication Date 4/18/2017 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM318435
Synonyms:
((2S,4R)-1-(2,2-diphenylacetyl)-4-((3-(4-fluorophenyl)prop-2-yn-1-yl)(methyl)amino)piperidine-2-carboxylic acid | US9624234, 46
Type:
Small organic molecule
Emp. Form.:
C32H33FN2O3
Mol. Mass.:
512.6144
SMILES:
CC(C#CCN(C)[C@H]1CCN([C@@H](C1)C(O)=O)C(=O)C(c1ccccc1)c1ccccc1)c1ccc(F)cc1
Structure:
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