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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM319569
Substrate
n/a
Meas. Tech.
IRAK4 Enzymatic DELFIA Assay, Protocol A
IC50
38.5±n/a nM
Citation
 Lee, KL; Allais, CP; Dehnhardt, CM; Gavrin, LK; Han, S; Hepworth, D; Lee, A; Lovering, FE; Mathias, JP; Owen, DR; Papaioannou, N; Saiah, E; Strohbach, JW; Trzupek, JD; Wright, SW; Zapf, CW Bicyclic-fused heteroaryl or aryl compounds as IRAK4 modulators US Patent  US10174000 Publication Date 1/8/2019 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM319569
Synonyms:
1-(((4S,7R)-7-fluoro-6-oxo-5-azaspiro[2.4]heptan-4-yl)methoxy)-7-methoxyisoquinoline-6-carboxamide | US10174000, Example 21
Type:
Small organic molecule
Emp. Form.:
C18H18FN3O4
Mol. Mass.:
359.3516
SMILES:
COc1cc2c(OC[C@H]3NC(=O)[C@H](F)C33CC3)nccc2cc1C(N)=O |r|
Structure:
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