Reaction Details Report a problem with these data
Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM319576
Substrate
n/a
Meas. Tech.
IRAK4 Enzymatic DELFIA Assay, Protocol A
IC50
1900±n/a nM
Citation
Lee, KL; Allais, CP; Dehnhardt, CM; Gavrin, LK; Han, S; Hepworth, D; Lee, A; Lovering, FE; Mathias, JP; Owen, DR; Papaioannou, N; Saiah, E; Strohbach, JW; Trzupek, JD; Wright, SW; Zapf, CW Bicyclic-fused heteroaryl or aryl compounds as IRAK4 modulators US Patent US10174000 Publication Date 1/8/2019
More Info.:
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
Inhibitor
Name:
BDBM319576
Synonyms:
(3S,6R)-5-oxo-2,3,4,5,6,7,9,10-octahydro-12,14-(ethanediylidene)-3,6-methanopyrido[2,3-l][1,4,11,8]trioxazacyclopentadecine-19-carboxamide | US10174000, Example 28
Type:
Small organic molecule
Emp. Form.:
C18H19N3O5
Mol. Mass.:
357.3606
SMILES:
NC(=O)c1cc2ccnc3OC[C@@H]4C[C@H](COCCOc1cc23)C(=O)N4 |r|