Reaction Details Report a problem with these data
Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM319581
Substrate
n/a
Meas. Tech.
IRAK4 Enzymatic DELFIA Assay, Protocol B
IC50
2000±n/a nM
Citation
Lee, KL; Allais, CP; Dehnhardt, CM; Gavrin, LK; Han, S; Hepworth, D; Lee, A; Lovering, FE; Mathias, JP; Owen, DR; Papaioannou, N; Saiah, E; Strohbach, JW; Trzupek, JD; Wright, SW; Zapf, CW Bicyclic-fused heteroaryl or aryl compounds as IRAK4 modulators US Patent US10174000 Publication Date 1/8/2019
More Info.:
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
Inhibitor
Name:
BDBM319581
Synonyms:
1-(((2S,3S,4S)-4-fluoro-3-methyl-5-oxopyrrolidin-2-yl)methoxy)-7-methoxy-N-methylisoquinoline-6-carboxamide | US10174000, Example 33
Type:
Small organic molecule
Emp. Form.:
C17H19FN4O4
Mol. Mass.:
362.3556
SMILES:
CNC(=O)c1nc2ccnc(OC[C@H]3NC(=O)[C@@H](F)[C@H]3C)c2cc1OC |r|