Reaction Details Report a problem with these data
Target
Phosphatidylinositol 3-kinase regulatory subunit beta
Ligand
BDBM320551
Substrate
n/a
Meas. Tech.
In Vitro Enzyme PI3K Assay
IC50
9909±n/a nM
Citation
 Samby, KK; Surase, YB; Amale, SR; Gorla, SK; Patel, P; Verma, AK 6-morpholinyl-2-pyrazolyl-9H-purine derivatives and their use as PI3K inhibitors US Patent  US10174035 Publication Date 1/8/2019 
Target
Name:
Phosphatidylinositol 3-kinase regulatory subunit beta
Synonyms:
P85B_HUMAN | PI3-kinase regulatory subunit beta | PI3-kinase subunit p85-beta | PI3K regulatory subunit beta | PIK3R2 | Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta | PtdIns-3-kinase regulatory subunit beta | PtdIns-3-kinase regulatory subunit p85-beta
Type:
Enzyme Subunit
Mol. Mass.:
81542.75
Organism:
Homo sapiens (Human)
Description:
O00459
Residue:
728
Sequence:
MAGPEGFQYRALYPFRRERPEDLELLPGDVLVVSRAALQALGVAEGGERCPQSVGWMPGLNERTRQRGDFPGTYVEFLGPVALARPGPRPRGPRPLPARPRDGAPEPGLTLPDLPEQFSPPDVAPPLLVKLVEAIERTGLDSESHYRPELPAPRTDWSLSDVDQWDTAALADGIKSFLLALPAPLVTPEASAEARRALREAAGPVGPALEPPTLPLHRALTLRFLLQHLGRVASRAPALGPAVRALGATFGPLLLRAPPPPSSPPPGGAPDGSEPSPDFPALLVEKLLQEHLEEQEVAPPALPPKPPKAKPASTVLANGGSPPSLQDAEWYWGDISREEVNEKLRDTPDGTFLVRDASSKIQGEYTLTLRKGGNNKLIKVFHRDGHYGFSEPLTFCSVVDLINHYRHESLAQYNAKLDTRLLYPVSKYQQDQIVKEDSVEAVGAQLKVYHQQYQDKSREYDQLYEEYTRTSQELQMKRTAIEAFNETIKIFEEQGQTQEKCSKEYLERFRREGNEKEMQRILLNSERLKSRIAEIHESRTKLEQQLRAQASDNREIDKRMNSLKPDLMQLRKIRDQYLVWLTQKGARQKKINEWLGIKNETEDQYALMEDEDDLPHHEERTWYVGKINRTQAEEMLSGKRDGTFLIRESSQRGCYACSVVVDGDTKHCVIYRTATGFGFAEPYNLYGSLKELVLHYQHASLVQHNDALTVTLAHPVRAPGPGPPPAAR
  
Inhibitor
Name:
BDBM320551
Synonyms:
US10174035, Compound 94 | [5-(1,3-Dimethyl-1H-pyrazol-4-yl)-7-(morpholin-4-yl)-3H-imidazo[4,5-b]pyridin-2-yl][4-(morpholin-4-yl)piperidin-1-yl]methanone
Type:
Small organic molecule
Emp. Form.:
C25H34N8O3
Mol. Mass.:
494.5893
SMILES:
Cc1nn(C)cc1-c1cc(N2CCOCC2)c2nc([nH]c2n1)C(=O)N1CCC(CC1)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: