Reaction Details Report a problem with these data
Target
Carbonic anhydrase 4
Ligand
BDBM11355
Substrate
BDBM11326
Meas. Tech.
Carbonic Anhydrase Enzyme Inhibition Assay
Ki
>200±n/a nM
Citation
Scozzafava, A; Supuran, CT Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes. J Med Chem 43:3677-87 (2000) [PubMed] Article
More Info.:
Target
Name:
Carbonic anhydrase 4
Synonyms:
CA-IV | CA4 | CAH4_BOVIN | Carbonate dehydratase IV | Carbonic Anhydrase IV | Carbonic anhydrase | Carbonic anhydrase 4
Type:
Enzyme
Mol. Mass.:
35152.74
Organism:
Bos taurus (bovine)
Description:
Bovine isozyme, isolated from lung microsomes
Residue:
312
Sequence:
MRLLLALLVLAAAPPQARAASHWCYQIQVKPSNYTCLEPDEWEGSCQNNRQSPVNIVTAKTQLDPNLGRFSFSGYNMKHQWVVQNNGHTVMVLLENKPSIAGGGLSTRYQATQLHLHWSRAMDRGSEHSFDGERFAMEMHIVHEKEKGLSGNASQNQFAEDEIAVLAFMVEDGSKNVNFQPLVEALSDIPRPNMNTTMKEGVSLFDLLPEEESLRHYFRYLGSLTTPTCDEKVVWTVFQKPIQLHRDQILAFSQKLFYDDQQKVNMTDNVRPVQSLGQRQVFRSGAPGLLLAQPLPTLLAPVLACLTVGFLR
Inhibitor
Name:
BDBM11355
Synonyms:
Hydroxamate 36 | N-hydroxy-2-[(4-methoxybenzene)[(4-nitrophenyl)methyl]sulfonamido]acetamide
Type:
Small organic molecule
Emp. Form.:
C16H17N3O7S
Mol. Mass.:
395.387
SMILES:
COc1ccc(cc1)S(=O)(=O)N(CC(=O)NO)Cc1ccc(cc1)N(=O)=O