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Target
Neuronal acetylcholine receptor subunit alpha-7
Ligand
BDBM322217
Substrate
n/a
Meas. Tech.
Human alpha7 nAChR Binding Assay
Ki
380±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; Koenig, G; Mcriner, AJ Geminal substituted quinuclidine amide compounds as agonists of α-7 nicotonic acetylcholine receptors US Patent  US10183938 Publication Date 1/22/2019 
Target
Name:
Neuronal acetylcholine receptor subunit alpha-7
Synonyms:
ACHA7_HUMAN | CHRNA7 | Cholinergic, Nicotinic Alpha7 | NACHRA7 | Neuronal acetylcholine receptor protein alpha-7 subunit | Neuronal acetylcholine receptor subunit alpha-7 (nAChR-alpha 7) | Nicotinic acetylcholine receptor alpha-7 (alpha7 nAChR)
Type:
n/a
Mol. Mass.:
56448.33
Organism:
Homo sapiens (Human)
Description:
CHRNA7 (NACHRA7)
Residue:
502
Sequence:
MRCSPGGVWLALAASLLHVSLQGEFQRKLYKELVKNYNPLERPVANDSQPLTVYFSLSLLQIMDVDEKNQVLTTNIWLQMSWTDHYLQWNVSEYPGVKTVRFPDGQIWKPDILLYNSADERFDATFHTNVLVNSSGHCQYLPPGIFKSSCYIDVRWFPFDVQHCKLKFGSWSYGGWSLDLQMQEADISGYIPNGEWDLVGIPGKRSERFYECCKEPYPDVTFTVTMRRRTLYYGLNLLIPCVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFASTMIIVGLSVVVTVIVLQYHHHDPDGGKMPKWTRVILLNWCAWFLRMKRPGEDKVRPACQHKQRRCSLASVEMSAVAPPPASNGNLLYIGFRGLDGVHCVPTPDSGVVCGRMACSPTHDEHLLHGGQPPEGDPDLAKILEEVRYIANRFRCQDESEAVCSEWKFAACVVDRLCLMAFSVFTIICTIGILMSAPNFVEAVSKDFA
  
Inhibitor
Name:
BDBM322217
Synonyms:
(R)-N-(2,2-dimethylquinuclidin-3-yl)-6-methylbenzo[b]thiophene-2-carboxamide | US10183938, Compound (R)-15
Type:
Small organic molecule
Emp. Form.:
C19H24N2OS
Mol. Mass.:
328.472
SMILES:
Cc1ccc2cc(sc2c1)C(=O)N[C@@H]1C2CCN(CC2)C1(C)C |wD:13.14,(-6.65,.98,;-5.32,.21,;-5.32,-1.33,;-3.98,-2.1,;-2.65,-1.33,;-1.18,-1.81,;-.28,-.56,;-1.18,.68,;-2.65,.21,;-3.98,.98,;1.26,-.56,;2.03,-1.9,;2.03,.77,;3.57,.77,;4.34,2.1,;5.37,1.59,;5.95,.59,;5.88,-.56,;6.65,.77,;5.88,2.1,;4.34,-.56,;4.34,-2.1,;3.01,-1.33,)|
Structure:
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