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Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM322217
Substrate
n/a
Meas. Tech.
[3H]BRL 43694 Competition Binding (h-5HT3 Assay
Ki
>10000±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; Koenig, G; Mcriner, AJ Geminal substituted quinuclidine amide compounds as agonists of α-7 nicotonic acetylcholine receptors US Patent  US10183938 Publication Date 1/22/2019 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:
Protein
Mol. Mass.:
55283.27
Organism:
Homo sapiens (Human)
Description:
P46098
Residue:
478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
  
Inhibitor
Name:
BDBM322217
Synonyms:
(R)-N-(2,2-dimethylquinuclidin-3-yl)-6-methylbenzo[b]thiophene-2-carboxamide | US10183938, Compound (R)-15
Type:
Small organic molecule
Emp. Form.:
C19H24N2OS
Mol. Mass.:
328.472
SMILES:
Cc1ccc2cc(sc2c1)C(=O)N[C@@H]1C2CCN(CC2)C1(C)C |wD:13.14,(-6.65,.98,;-5.32,.21,;-5.32,-1.33,;-3.98,-2.1,;-2.65,-1.33,;-1.18,-1.81,;-.28,-.56,;-1.18,.68,;-2.65,.21,;-3.98,.98,;1.26,-.56,;2.03,-1.9,;2.03,.77,;3.57,.77,;4.34,2.1,;5.37,1.59,;5.95,.59,;5.88,-.56,;6.65,.77,;5.88,2.1,;4.34,-.56,;4.34,-2.1,;3.01,-1.33,)|
Structure:
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