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Target
5-hydroxytryptamine receptor 3A
Ligand
BDBM322226
Substrate
n/a
Meas. Tech.
[3H]BRL 43694 Competition Binding (h-5HT3 Assay
Ki
1600±n/a nM
Citation
 Acharya, R; Burnett, DA; Bursavich, MG; Cook, AS; Harrison, BA; Koenig, G; Mcriner, AJ Geminal substituted quinuclidine amide compounds as agonists of α-7 nicotonic acetylcholine receptors US Patent  US10183938 Publication Date 1/22/2019 
Target
Name:
5-hydroxytryptamine receptor 3A
Synonyms:
5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3
Type:
Protein
Mol. Mass.:
55283.27
Organism:
Homo sapiens (Human)
Description:
P46098
Residue:
478
Sequence:
MLLWVQQALLALLLPTLLAQGEARRSRNTTRPALLRLSDYLLTNYRKGVRPVRDWRKPTTVSIDVIVYAILNVDEKNQVLTTYIWYRQYWTDEFLQWNPEDFDNITKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYIRHQGEVQNYKPLQVVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINISLWRLPEKVKSDRSVFMNQGEWELLGVLPYFREFSMESSNYYAEMKFYVVIRRRPLFYVVSLLLPSIFLMVMDIVGFYLPPNSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQQPVPAWLRHLVLERIAWLLCLREQSTSQRPPATSQATKTDDCSAMGNHCSHMGGPQDFEKSPRDRCSPPPPPREASLAVCGLLQELSSIRQFLEKRDEIREVARDWLRVGSVLDKLLFHIYLLAVLAYSITLVMLWSIWQYA
  
Inhibitor
Name:
BDBM322226
Synonyms:
(R)-5-cyclopropyl-N-(2,2-dimethylquinuclidin-3-yl)benzo[b]thiophene-2-carboxamide | US10183938, Compound (R)-19
Type:
Small organic molecule
Emp. Form.:
C21H26N2OS
Mol. Mass.:
354.509
SMILES:
CC1(C)[C@H](NC(=O)c2cc3cc(ccc3s2)C2CC2)C2CCN1CC2 |wD:3.3,(5.11,-1.44,;5.11,.1,;3.78,-.67,;4.34,1.44,;2.8,1.44,;2.03,.1,;2.8,-1.23,;.49,.1,;-.41,-1.14,;-1.88,-.67,;-3.21,-1.44,;-4.55,-.67,;-4.55,.87,;-3.21,1.64,;-1.88,.87,;-.41,1.35,;-5.88,-1.44,;-6.65,-2.77,;-7.42,-1.44,;5.11,2.77,;6.14,2.26,;6.72,1.26,;6.65,.1,;7.42,1.44,;6.65,2.77,)|
Structure:
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