Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM143788
Substrate
n/a
Meas. Tech.
Human Orexin 2 Receptor Ca2+ Mobilization Assay
Ki
443±n/a nM
Citation
 Gelin, CF; Lebold, TP; Shireman, BT; Ziff, JM Substituted 2-azabicycles and their use as orexin receptor modulators US Patent  US10183953 Publication Date 1/22/2019 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM143788
Synonyms:
US10183953, Example 49 | US8969352, 49 | US9611277, Example 49 | US9845333, 49
Type:
Small organic molecule
Emp. Form.:
C20H18BrN5O2
Mol. Mass.:
440.293
SMILES:
Brc1ccc(OC2CC3CC2N(C3)C(=O)c2ccccc2-n2nccn2)nc1 |TLB:13:11:6.7:9,THB:5:6:11.12:9|
Structure:
Search PDB for entries with ligand similarity: