Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 4
Ligand
BDBM91597
Substrate
n/a
Meas. Tech.
Omnia Assay
IC50
>1000±n/a nM
Citation
 D Agostino, LA; Sjin, RT; Niu, D; McDonald, JJ; Zhu, Z; Liu, H; Mazdiyasni, H; Petter, RC; Singh, J; Barrague, M; Gross, A; Munson, M Heteroaryl compounds and uses thereof US Patent  US10189794 Publication Date 1/29/2019 
Target
Name:
Fibroblast growth factor receptor 4
Synonyms:
CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF
Type:
Protein
Mol. Mass.:
87957.45
Organism:
Homo sapiens (Human)
Description:
P22455
Residue:
802
Sequence:
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
  
Inhibitor
Name:
BDBM91597
Synonyms:
US10189794, Compound I-51 | US10618902, Compound I-51 | US10774052, Compound I-51 | US9695132, I-51
Type:
Small organic molecule
Emp. Form.:
C19H20N6O2
Mol. Mass.:
364.4011
SMILES:
CN1C(=O)N(Cc2cnc(Nc3ccccc3NC(=O)C=C)nc12)C1CC1 |$;;;;;;;;;;;;;;;;;HN;;;;;;;;;$|
Structure:
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