Reaction Details Report a problem with these data
Target
Carbonic anhydrase 4
Ligand
BDBM11631
Substrate
BDBM10856
Meas. Tech.
CA Inhibition Assay
Ki
1.7±n/a nM
Citation
Ilies, MA; Vullo, D; Pastorek, J; Scozzafava, A; Ilies, M; Caproiu, MT; Pastorekova, S; Supuran, CT Carbonic anhydrase inhibitors. Inhibition of tumor-associated isozyme IX by halogenosulfanilamide and halogenophenylaminobenzolamide derivatives. J Med Chem 46:2187-96 (2003) [PubMed] Article
More Info.:
Target
Name:
Carbonic anhydrase 4
Synonyms:
CA-IV | CA4 | CAH4_BOVIN | Carbonate dehydratase IV | Carbonic Anhydrase IV | Carbonic anhydrase | Carbonic anhydrase 4
Type:
Enzyme
Mol. Mass.:
35152.74
Organism:
Bos taurus (bovine)
Description:
Bovine isozyme, isolated from lung microsomes
Residue:
312
Sequence:
MRLLLALLVLAAAPPQARAASHWCYQIQVKPSNYTCLEPDEWEGSCQNNRQSPVNIVTAKTQLDPNLGRFSFSGYNMKHQWVVQNNGHTVMVLLENKPSIAGGGLSTRYQATQLHLHWSRAMDRGSEHSFDGERFAMEMHIVHEKEKGLSGNASQNQFAEDEIAVLAFMVEDGSKNVNFQPLVEALSDIPRPNMNTTMKEGVSLFDLLPEEESLRHYFRYLGSLTTPTCDEKVVWTVFQKPIQLHRDQILAFSQKLFYDDQQKVNMTDNVRPVQSLGQRQVFRSGAPGLLLAQPLPTLLAPVLACLTVGFLR
Inhibitor
Name:
BDBM11631
Synonyms:
2-N-(4-amino-3,5-dibromobenzene)-1,3,4-thiadiazole-2,5-disulfonamide | 5-(4-Amino-3,5-dibromobenzenesulfonamido)-1,3,4-thiadiazole-2-sulfonamide | aminobenzolamide 24
Type:
Small organic molecule
Emp. Form.:
C8H7Br2N5O4S3
Mol. Mass.:
493.175
SMILES:
Nc1c(Br)cc(cc1Br)S(=O)(=O)Nc1nnc(s1)S(N)(=O)=O