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Target
Cytochrome P450 11B1, mitochondrial
Ligand
BDBM325780
Substrate
n/a
Meas. Tech.
G402-Based Assay
EC50
4083±n/a nM
Citation
 Aebi, J; Amrein, K; Britton, R; Hornsperger, B; Kuhn, B; Maerki, HP; Martin, RE; Mayweg, AV; Tan, X Phenyl-dihydropyridine derivatives as aldosterone synthase inhibitors US Patent  US9636339 Publication Date 5/2/2017 
Target
Name:
Cytochrome P450 11B1, mitochondrial
Synonyms:
C11B1_HUMAN | CYP11B1 | CYPXIB1 | Cytochrome P450 11B, mitochondrial precursor | Cytochrome P450 11B1 | Cytochrome P450 11B1 (CYP11B1) | Cytochrome P450 11B1, mitochondrial | S11BH
Type:
Enzyme
Mol. Mass.:
57591.44
Organism:
Homo sapiens (Human)
Description:
P15538
Residue:
503
Sequence:
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN
  
Inhibitor
Name:
BDBM325780
Synonyms:
(rac)-N-Ethyl-2-[4-[2-fluoro-4-(trifluoromethyl)phenyl]-5,6,7,8-tetrahydroisoquinolin-8-yl]acetamide | US9636339, 29
Type:
Small organic molecule
Emp. Form.:
C20H20F4N2O
Mol. Mass.:
380.3792
SMILES:
CCNC(=O)CC1CCCc2c1cncc2-c1ccc(cc1F)C(F)(F)F
Structure:
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