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Target
Leukotriene A-4 hydrolase
Ligand
BDBM327182
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
0.160±n/a nM
Citation
 Bylock, LA Benzodioxane inhibitors of leukotriene production for combination therapy US Patent  US9662339 Publication Date 5/30/2017 
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:
Hydrolase; metalloprotease
Mol. Mass.:
69280.41
Organism:
Homo sapiens (Human)
Description:
Human recombinant LTA4H.
Residue:
611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
  
Inhibitor
Name:
BDBM327182
Synonyms:
4-{1-[(S)-4-(2,3-Dihydro- [1,4]dioxino[2,3-b]pyridin-3-yl)- benzyl]-piperidin-4-yl]- cyclohexanecarboxylic acid | US9662339, 265
Type:
Small organic molecule
Emp. Form.:
C26H32N2O4
Mol. Mass.:
436.5433
SMILES:
OC(=O)C1CCC(CC1)C1CCN(Cc2ccc(cc2)[C@H]2COc3cccnc3O2)CC1 |r,wU:20.21,(10.67,-1.15,;9.34,-1.93,;9.34,-3.47,;8,-1.15,;6.67,-1.93,;5.33,-1.15,;5.33,.38,;6.67,1.15,;8,.38,;4,1.15,;2.67,.38,;1.33,1.15,;1.33,2.69,;,3.47,;-1.33,2.69,;-1.33,1.15,;-2.67,.38,;-4,1.15,;-4,2.69,;-2.67,3.46,;-5.33,.38,;-5.33,-1.16,;-6.67,-1.93,;-8,-1.16,;-9.34,-1.93,;-10.67,-1.16,;-10.67,.38,;-9.34,1.15,;-8,.38,;-6.67,1.15,;2.67,3.47,;4,2.69,)|
Structure:
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