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Target
Leukotriene A-4 hydrolase
Ligand
BDBM327190
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
0.160±n/a nM
Citation
 Bylock, LA Benzodioxane inhibitors of leukotriene production for combination therapy US Patent  US9662339 Publication Date 5/30/2017 
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:
Hydrolase; metalloprotease
Mol. Mass.:
69280.41
Organism:
Homo sapiens (Human)
Description:
Human recombinant LTA4H.
Residue:
611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
  
Inhibitor
Name:
BDBM327190
Synonyms:
US9662339, 273 | {(exo)-8-[(S)-4-(2,3-Dihydro- [1,4]dioxino[2,3-b]pyridin-3-yl)- benzyl]-8-aza-bicyclo[3.2.1]oct-3- yl}-urea
Type:
Small organic molecule
Emp. Form.:
C22H26N4O3
Mol. Mass.:
394.4668
SMILES:
NC(=O)N[C@H]1C[C@@H]2CC[C@H](C1)N2Cc1ccc(cc1)[C@H]1COc2cccnc2O1 |r,THB:12:11:10.4.5:8.7|
Structure:
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