Reaction Details Report a problem with these data
Target
Nuclear receptor ROR-gamma
Ligand
BDBM330793
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay (SPA) Binding Assay
IC50
172±n/a nM
Citation
 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS RORγ modulators US Patent  US9725443 Publication Date 8/8/2017 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM330793
Synonyms:
(S)-1,1,1,3,3,3-hexafluoro-2-(1-((4-fluorophenyl)sulfonyl)-2-((5-(methylsulfonyl)-1,3,4-thiadiazol-2-yl)methyl)-1,2,3,4-tetrahydroquinolin-6-yl)propan-2-ol | US9725443, 7
Type:
Small organic molecule
Emp. Form.:
C22H18F7N3O5S3
Mol. Mass.:
633.579
SMILES:
CS(=O)(=O)c1nnc(C[C@@H]2CCc3cc(ccc3N2S(=O)(=O)c2ccc(F)cc2)C(O)(C(F)(F)F)C(F)(F)F)s1 |r|
Structure:
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