Reaction Details Report a problem with these data
Target
Nuclear receptor ROR-gamma
Ligand
BDBM330799
Substrate
n/a
Meas. Tech.
Scintillation Proximity Assay (SPA) Binding Assay
IC50
27.0±n/a nM
Citation
 Dhar, TG; Duan, J; Gong, H; Jiang, B; Lu, Z; Weinstein, DS RORγ modulators US Patent  US9725443 Publication Date 8/8/2017 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM330799
Synonyms:
(S)-1,1,1,3,3,3-hexafluoro-2-(1-((4-fluorophenyl)sulfonyl)-2-((5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)methyl)-1,2,3,4-tetrahydroquinolin-6-yl)propan-2-ol | US9725443, 13
Type:
Small organic molecule
Emp. Form.:
C26H19F7N4O4S
Mol. Mass.:
616.507
SMILES:
OC(c1ccc2N([C@H](Cc3nnc(o3)-c3ccncc3)CCc2c1)S(=O)(=O)c1ccc(F)cc1)(C(F)(F)F)C(F)(F)F |r|
Structure:
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