Reaction Details Report a problem with these data
Target
High affinity nerve growth factor receptor [441-796]
Ligand
BDBM136620
Substrate
n/a
Meas. Tech.
ELISA Assay
pH
7.5±n/a
IC50
8.7±n/a nM
Comments
extracted
Citation
Haas, J; Andrews, SW; Jiang, Y; Zhang, G Method of treatment using substituted pyrazolo[1,5-A] pyrimidine compounds US Patent US9676783 Publication Date 6/13/2017
More Info.:
Target
Name:
High affinity nerve growth factor receptor [441-796]
Synonyms:
MTC | NTRK1 | NTRK1_HUMAN | TRK | TRKA | Tyrosine kinase receptor A | Tyrosine kinase receptor A (TrkA)
Type:
Protein
Mol. Mass.:
39939.20
Organism:
Homo sapiens (Human)
Description:
Human his-tagged TrkA cytoplasmic domain (441-796 aa)
Residue:
356
Sequence:
KCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
Inhibitor
Name:
BDBM136620
Synonyms:
US10005783, 37 | US10047097, 37 | US10774085, Example 37 | US11267818, Example 37 | US8865698, 37 | US9676783, 37
Type:
Small organic molecule
Emp. Form.:
C22H23F3N6O2
Mol. Mass.:
460.4522
SMILES:
O[C@H]1CCN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)F |r|