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Target
Fibroblast growth factor receptor 4
Ligand
BDBM333160
Substrate
n/a
Meas. Tech.
FGFR-4 wild type assay
IC50
<10±n/a nM
Citation
 Miduturu, CV Inhibitors of the fibroblast growth factor receptor US Patent  US10196436 Publication Date 2/5/2019 
Target
Name:
Fibroblast growth factor receptor 4
Synonyms:
CD_antigen: CD334 FGFR4 | FGFR-4 | FGFR4 | FGFR4_HUMAN | Fibroblast growth factor receptor | Fibroblast growth factor receptor 4 (FGFR4) | JK2 | JTK2 | TKF
Type:
Protein
Mol. Mass.:
87957.45
Organism:
Homo sapiens (Human)
Description:
P22455
Residue:
802
Sequence:
MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT
  
Inhibitor
Name:
BDBM333160
Synonyms:
US10196436, Compound 12
Type:
Small organic molecule
Emp. Form.:
C20H18Cl2N4O4
Mol. Mass.:
449.287
SMILES:
COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(nc2n(C)c1=O)N(C)C(=O)C=C |(-3.33,7.7,;-3.33,6.16,;-2,5.39,;-.67,6.16,;.67,5.39,;2,6.16,;3.33,5.39,;.67,3.85,;2,3.08,;-.67,3.08,;-2,3.85,;-3.33,3.08,;-.67,1.54,;-2,.77,;-2,-.77,;-3.33,-1.54,;-3.33,-3.08,;-2,-3.85,;-.67,-3.08,;-.67,-1.54,;.67,-.77,;2,-1.54,;.67,.77,;2,1.54,;-2,-5.39,;-3.33,-6.16,;-.67,-6.16,;-.67,-7.7,;.67,-5.39,;2,-6.16,)|
Structure:
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