Reaction Details Report a problem with these data
Target
Fibroblast growth factor receptor 1
Ligand
BDBM333192
Substrate
n/a
Meas. Tech.
FGFR-1 wild type assay
IC50
55±n/a nM
Citation
 Miduturu, CV Inhibitors of the fibroblast growth factor receptor US Patent  US10196436 Publication Date 2/5/2019 
Target
Name:
Fibroblast growth factor receptor 1
Synonyms:
BFGFR | Basic fibroblast growth factor receptor 1 | Basic fibroblast growth factor receptor 1 (FGFR1) | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR-1 Tyrosine Kinase | FGFR-1, (FL) | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor (FGFR) | Fibroblast growth factor receptor 1 (FGFR-1) | Fibroblast growth factor receptor 1 (FGFR1) | Fms-like tyrosine kinase 2 | HBGFR | N-sam | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | bFGF-R | c-fgr
Type:
Receptor
Mol. Mass.:
91861.70
Organism:
Homo sapiens (Human)
Description:
P11362
Residue:
822
Sequence:
MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
  
Inhibitor
Name:
BDBM333192
Synonyms:
US10196436, Compound 42
Type:
Small organic molecule
Emp. Form.:
C27H24Cl2N4O4
Mol. Mass.:
539.41
SMILES:
COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(Nc3c(C)cccc3NC(=O)C=C)nc2cc1OC |(-3.33,10.01,;-3.33,8.47,;-2,7.7,;-.67,8.47,;.67,7.7,;2,8.47,;3.33,7.7,;.67,6.16,;2,5.39,;-.67,5.39,;-2,6.16,;-3.33,5.39,;-.67,3.85,;-2,3.08,;-2,1.54,;-3.33,.77,;-3.33,-.77,;-2,-1.54,;-2,-3.08,;-.67,-3.85,;.67,-3.08,;.67,-1.54,;2,-3.85,;2,-5.39,;.67,-6.16,;-.67,-5.39,;-2,-6.16,;-2,-7.7,;-.67,-8.47,;-3.33,-8.47,;-3.33,-10.01,;-.67,-.77,;-.67,.77,;.67,1.54,;.67,3.08,;2,3.85,;3.33,3.08,)|
Structure:
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