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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM12915
Substrate
S6 Peptide Substrate
Meas. Tech.
Kinase Assay
pH
7.6±n/a
Temperature
303.15±n/a K
IC50
4000±n/a nM
Citation
 Jacobs, MD; Black, J; Futer, O; Swenson, L; Hare, B; Fleming, M; Saxena, K Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002. J Biol Chem 280:13728-34 (2005) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM12915
Synonyms:
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | 2-(morpholin-4-yl)-8-phenyl-4H-chromen-4-one | CHEMBL98350 | LY294002 | US10308662, Compound LY294002 | US9505780, LY294002
Type:
Small organic molecule
Emp. Form.:
C19H17NO3
Mol. Mass.:
307.3432
SMILES:
O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
S6 Peptide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
1118.34
Organism:
n/a
Description:
n/a
Residue:
9
Sequence:
RRRLSSLRA