Reaction Details Report a problem with these data
Target
P2X purinoceptor 3
Ligand
BDBM271529
Substrate
n/a
Meas. Tech.
Receptor Inhibition Assay
IC50
176±n/a nM
Citation
 Kai, H Aminotriazine derivative and pharmaceutical composition comprising the same US Patent  US9732060 Publication Date 8/15/2017 
Target
Name:
P2X purinoceptor 3
Synonyms:
ATP receptor | Glucocorticoid receptor | P2RX3 | P2RX3_HUMAN | P2X purinoceptor 3 | P2X purinoceptor 3 (P2RX3) | P2X purinoceptor 3 (P2X3) | P2X3 | P2X3 purinoceptor | Purinergic receptor | p2x3 + hsa
Type:
Protein
Mol. Mass.:
44292.02
Organism:
Homo sapiens (Human)
Description:
P56373
Residue:
397
Sequence:
MNCISDFFTYETTKSVVVKSWTIGIINRVVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGSGLYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPESEEKYRCVSDSQCGPERLPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVETPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTARDMKTCRFHPDKDPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDSVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADQYKAKKFEEVNETTLKIAALTNPVYPSDQTTAEKQSTDSGAFSIGH
  
Inhibitor
Name:
BDBM271529
Synonyms:
US10065941, Compound I-030 | US9732060, Compound I-030
Type:
Small organic molecule
Emp. Form.:
C27H23ClF3N5O5
Mol. Mass.:
589.95
SMILES:
COC(=O)[C@@H](C)Cn1c(=O)[nH]\c(=N/c2ccc(Oc3ncccc3C(F)(F)F)cc2)n(Cc2ccc(Cl)cc2)c1=O |r|
Structure:
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