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Target
Tyrosine-protein kinase JAK1
Ligand
BDBM246871
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Zhou, J; Qiao, L; Weng, L Process for the synthesis of a phosphoinositide 3-kinase inhibitor US Patent  US9732097 Publication Date 8/15/2017 
Target
Name:
Tyrosine-protein kinase JAK1
Synonyms:
JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1
Type:
Protein
Mol. Mass.:
133293.73
Organism:
Homo sapiens (Human)
Description:
P23458
Residue:
1154
Sequence:
MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEELCIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTNDNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMNWFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIREEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTCFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFMLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSGTLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDSDSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRTSFQNLIEGFEALLK
  
Inhibitor
Name:
BDBM246871
Synonyms:
US10053465, 10 | US10065963, Compound 10 | US10125150, Example 10 | US10336759, # 10 | US10479803, Example 10 | US10519163, Example 10 | US10675284, Example 10 | US11084822, Example 10 | US11130767, # 10 | US11136326, Example 10 | US11304949, Compound 10 | US11324749, Comp. No. 10 | US11406640, Comp. No. 10 | US11596632, Comp. No. 10 | US20240058343, Compound 10 | US9732097, Example 10 | [trans-1-[4-(7H- pyrrolo[2,3- d]pyrimidin-4-yl)- 1H-pyrazol-1-yl]-3- (4-{[2- (trifluoromethyl) pyrimidin-4- yl]carbonyl} piperazin-1- yl)cyclobutyl] acetonitrile
Type:
Small organic molecule
Emp. Form.:
C25H23F3N10O
Mol. Mass.:
536.5117
SMILES:
FC(F)(F)c1nccc(n1)C(=O)N1CCN(CC1)[C@H]1C[C@@](CC#N)(C1)n1cc(cn1)-c1ncnc2[nH]ccc12 |r,wU:20.27,wD:18.19,(-2.27,10.39,;-.79,10,;.3,11.08,;-.79,11.54,;-.39,8.51,;1.1,8.11,;1.5,6.62,;.41,5.53,;-1.08,5.93,;-1.48,7.42,;-2.17,4.84,;-3.66,5.24,;-1.77,3.35,;-2.86,2.27,;-2.46,.78,;-.97,.38,;.12,1.47,;-.28,2.96,;-.57,-1.11,;-1.34,-2.44,;-.01,-3.21,;1.48,-3.61,;2.57,-2.52,;3.66,-1.43,;.76,-1.88,;-.78,-4.55,;-.3,-6.01,;-1.55,-6.92,;-2.8,-6.01,;-2.32,-4.55,;-1.55,-8.46,;-2.88,-9.23,;-2.88,-10.77,;-1.55,-11.54,;-.22,-10.77,;1.25,-11.24,;2.15,-10,;1.25,-8.75,;-.22,-9.23,)|
Structure:
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