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Target
NAD-dependent protein deacetylase sirtuin-2
Ligand
BDBM333461
Substrate
n/a
Meas. Tech.
Biochemical Deacetylation Assay
IC50
9000±n/a nM
Citation
 Kazantsev, AG; Thompson, LM; Abagyan, R; Casale, M Small molecule activators of NRF2 pathway US Patent  US9737525 Publication Date 8/22/2017 
Target
Name:
NAD-dependent protein deacetylase sirtuin-2
Synonyms:
NAD-Dependent Deacetylase Sirtuin-2 | NAD-dependent deacetylase sirtuin 2 | NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-2 (SIRT2) | SIR2-like | SIR2-like protein 2 | SIR2L | SIR2L2 | SIR2_HUMAN | SIRT2 | Sirtuin 2 (SIRT2)
Type:
Hydrolase
Mol. Mass.:
43172.62
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
389
Sequence:
MAEPDPSHPLETQAGKVQEAQDSDSDSEGGAAGGEADMDFLRNLFSQTLSLGSQKERLLDELTLEGVARYMQSERCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFFALAKELYPGQFKPTICHYFMRLLKDKGLLLRCYTQNIDTLERIAGLEQEDLVEAHGTFYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSDFLKVDLLLVMGTSLQVQPFASLISKAPLSTPRLLINKEKAGQSDPFLGMIMGLGGGMDFDSKKAYRDVAWLGECDQGCLALAELLGWKKELEDLVRREHASIDAQSGAGVPNPSTSASPKKSPPPAKDEARTTEREKPQ
  
Inhibitor
Name:
BDBM333461
Synonyms:
US9737525, Compound MIND4-23
Type:
Small organic molecule
Emp. Form.:
C28H25N3O2S
Mol. Mass.:
467.582
SMILES:
COc1ccc(CSc2nnc(COc3cccc4ccccc34)n2Cc2ccccc2)cc1
Structure:
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