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Target
D-amino-acid oxidase
Ligand
BDBM337637
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
2500±n/a nM
Citation
 Farnaby, W; Fieldhouse, C; Hazel, K; Kerr, C; Kinsella, N; Livermore, D; Merchant, K; Miller, D Pyridazinones as DAAO enzyme inhibitors US Patent  US9750748 Publication Date 9/5/2017 
Target
Name:
D-amino-acid oxidase
Synonyms:
D-amino-acid oxidase (DAAO) | DAAO | DAMOX | DAO | OXDA_HUMAN
Type:
Homodimer
Mol. Mass.:
39476.06
Organism:
Homo sapiens (Human)
Description:
P14920
Residue:
347
Sequence:
MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLSDPNNPQEADWSQQTFDYLLSHVHSPNAENLGLFLISGYNLFHEAIPDPSWKDTVLGFRKLTPRELDMFPDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNCTGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGNWSELNNIQDHNTIWEGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPSNTEVIHNYGHGGYGLTIHWGCALEAAKLFGRILEEKKLSRMPPSHL
  
Inhibitor
Name:
BDBM337637
Synonyms:
6-(Azetidin-1-yl)-4-hydroxypyridazin-3(2H)-one | US9750748, 9
Type:
Small organic molecule
Emp. Form.:
C7H9N3O2
Mol. Mass.:
167.1653
SMILES:
Oc1cc(n[nH]c1=O)N1CCC1
Structure:
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