Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM337661
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
5.00±1.0 nM
Citation
 Sotomayor, EM; Bergman, JA; Kozikowski, AP; Villagra, AV; Woan, KV Selective histone deactylase 6 inhibitors US Patent  US9751832 Publication Date 9/5/2017 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM337661
Synonyms:
US10227295, Compound TSA | US11207431, TSA | US9751832, TSA | US9956192, Compound TSA
Type:
Small organic molecule
Emp. Form.:
C13H18N2O3
Mol. Mass.:
250.2936
SMILES:
ONC(=O)CCCCCC(=O)Nc1ccccc1
Structure:
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