Target
Calcium-dependent protein kinase 1
Ligand
BDBM340946
Substrate
n/a
Meas. Tech.
Biological Assay
IC50
5.30±n/a nM
Citation
 Van Voorhis, WCHol, WGLarson, ETMaly, DJMerritt, EOjo, KK Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases US Patent  US9765037 Publication Date 9/19/2017 
Target
Name:
Calcium-dependent protein kinase 1
Synonyms:
Calcium-dependent protein kinase 1 (CDPK1)
Type:
Protein
Mol. Mass.:
76617.33
Organism:
Cryptosporidium parvum
Description:
Q6S4W0
Residue:
677
Sequence:
MLNIEQNADECAKRVGANMVPVLHNVTEECNIKAEEKEIVPEVEEAKSESNNCLDSDDYLEGHIYAAMCTKCAGELQQKLNPTEPYRDPKKVSGKEQISRGLIIESKSFVDANKNIKFSKRSDKNEYAGLCSSPEVTTPNGERETSTDSNIKNTESTKVSHGIFDRTCLIQEHALVNRNINDFYELNLGNLGRGSYGSVVKAIDKQSGAQRAVKIILKPKLENINRLKREILIMKRLDHPNIIKLFEVFEDTNYLYFVMEICTGGELFDRIIKRGHFSERYAAVIMRQVFSAIAYCHSNEFMHRDLKPENLLFSDSSPNSLLKVIDWGFAAKCPKTHKFTSVVGTPYYVAPEVLYGSYSKLCDLWSAGVILYILLCGYPPFHGKDNVEILRKVKIGQYSLEHNSWKYVSDSAKDLIKRLLMTDPNKRISAQDALNHPWIKSQISSPNTADATYFTNDVCNSLLARFRDFQRQSKLKKLALTCVAYHLNDADIGALQKLFSTLDRNGDGVLTINEIRSALHKIQNVSQLGDDIDNLLMELDTDGNGRIDYTEFIAASIDHKLYEQESLCKAAFKVFDLDMDGRISPQELSRVLNITFLQEAFEQSTIDSLLKEVDINQDGYIDFNEFMKMMMGDKHEQKLETKVQKIEDEGSGNKKLSKGGIISDIFGATSIFKKLNN
  
Inhibitor
Name:
BDBM340946
Synonyms:
3-tert-butyl-1-(6-methoxynaphthalen-2- yl)imidazo[1,5-a]pyrazin-8-amine | US10544104, Compound 71 | US11247972, Compound 71 | US9765037, Compound 71
Type:
Small organic molecule
Emp. Form.:
C21H22N4O
Mol. Mass.:
346.4256
SMILES:
COc1ccc2cc(ccc2c1)-c1nc(n2ccnc(N)c12)C(C)(C)C
Structure:
Search PDB for entries with ligand similarity: