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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM340803
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
64.0±n/a nM
Citation
 Kiso, T; Tsukamoto, M Therapeutic agent for pain US Patent  US9765040 Publication Date 9/19/2017 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_RAT | Hsd11 | Hsd11b1
Type:
Enzyme
Mol. Mass.:
31889.48
Organism:
Rattus norvegicus (rat)
Description:
P16232
Residue:
288
Sequence:
MKKYLLPVLVLCLGYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMAFAERFVVEAGKLLGGLDMLILNHITQTTMSLFHDDIHSVRRSMEVNFLSYVVLSTAALPMLKQSNGSIAIISSMAGKMTQPLIASYSASKFALDGFFSTIRKEHLMTKVNVSITLCVLGFIDTETALKETSGIILSQAAPKEECALEIIKGTVLRKDEVYYDKSSWTPLLLGNPGRRIMEFLSLRSYNRDLFVSN
  
Inhibitor
Name:
BDBM340803
Synonyms:
US9765040, Compound 11
Type:
Small organic molecule
Emp. Form.:
C21H19F3N4O2
Mol. Mass.:
416.3964
SMILES:
CC(C)(Oc1ccc(F)cc1F)c1nnc(-c2ccc(cc2F)C(N)=O)n1C1CC1
Structure:
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