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Target
Tryptophan 5-hydroxylase 1
Ligand
BDBM341652
Substrate
n/a
Meas. Tech.
Biochemical In Vitro Assay
IC50
2.00±n/a nM
Citation
 Bur, D; Grisostomi, C; Nayler, O; Remen, L; Vercauteren, M; Welford, R Tricyclic piperidine compounds US Patent  US9765092 Publication Date 9/19/2017 
Target
Name:
Tryptophan 5-hydroxylase 1
Synonyms:
TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1
Type:
PROTEIN
Mol. Mass.:
50990.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1361824
Residue:
444
Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
  
Inhibitor
Name:
BDBM341652
Synonyms:
5-(6-(2-(2-chloro-4-(methylsulfonamido)phenoxy)-acetyl)-5,6,7,8-tetrahydrothiazolo[2',3':2,3]imidazo[4,5-c]pyridin-5-yl)-4-fluoro-N,N-dimethylthiophene-2-carboxamide | US9765092, Example 6.9.1
Type:
Small organic molecule
Emp. Form.:
C24H23ClFN5O5S3
Mol. Mass.:
612.116
SMILES:
CN(C)C(=O)c1cc(F)c(s1)C1N(CCc2nc3sccn3c12)C(=O)COc1ccc(NS(C)(=O)=O)cc1Cl
Structure:
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