Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 1
Ligand
BDBM204791
Substrate
n/a
Meas. Tech.
Active Human ERK2 (hERK2) Activity Assay
IC50
0.39±0 nM
Citation
 Lipford, K; Falcone, D; Sloman, DL; Witter, DJ ERK inhibitors US Patent  US9546168 Publication Date 1/17/2017 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM204791
Synonyms:
US9546168, ex 4
Type:
Small organic molecule
Emp. Form.:
C22H22N6O2
Mol. Mass.:
402.4491
SMILES:
C[C@@H](NC(=O)Nc1cc2[nH]nc(-c3ccnc(C)c3)c2c(CO)n1)c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: