Reaction Details Report a problem with these data
Target
Monocarboxylate transporter 4
Ligand
BDBM345271
Substrate
n/a
Meas. Tech.
Lactate Transport in MCT4-Expressing MDA-MB-453 Breast Cancer Cells
IC50
440±n/a nM
Citation
 Parnell, KM; McCall, J MCT4 inhibitors for treating disease US Patent  US10202350 Publication Date 2/12/2019 
Target
Name:
Monocarboxylate transporter 4
Synonyms:
MCT 4 | MCT3 | MCT4 | MOT4_HUMAN | SLC16A3 | Solute carrier family 16 member 3
Type:
PROTEIN
Mol. Mass.:
49474.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104604
Residue:
465
Sequence:
MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPEVAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
  
Inhibitor
Name:
BDBM345271
Synonyms:
1-[[5-(4-Chlorophenyl)-1-[(2- chlorophenyl)methyl]pyrazol-3- yl]methoxy]cyclopropanecarboxylic acid 1H NMR (CD3OD, 400 MHz) $#948; 1.18- 1.32 (m, 3H), 1.64-1.80 (m, 1H), 4.61 (s, 2H), 5.42 (s, 2H), 6.52 (s, 1H), 6.60-6.80 (m, 1H), 7.20-52 (m, 7H). | US10202350, Example 17 | US10214492, Example 17 | US11292767, Example 17 | US11724989, Example 17
Type:
Small organic molecule
Emp. Form.:
C21H18Cl2N2O3
Mol. Mass.:
417.285
SMILES:
OC(=O)C1(CC1)OCc1cc(-c2ccc(Cl)cc2)n(Cc2ccccc2Cl)n1
Structure:
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