Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM347293
Substrate
n/a
Meas. Tech.
n-Vitro Fluorescence Assay for Identification of Renin-Inhibitory Activity
IC50
>30000±n/a nM
Citation
 Klein, M Hydroxy-ethylene derivatives for the treatment of arthrosis US Patent  US10202418 Publication Date 2/12/2019 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM347293
Synonyms:
US10202418, Compound A5
Type:
Small organic molecule
Emp. Form.:
C35H45N3O6
Mol. Mass.:
603.7483
SMILES:
COc1ccc(CC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc2ccccc2)[C@@H](O)CCC(=O)NCCc2ccccc2)cc1OC |r|
Structure:
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