Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM347298
Substrate
n/a
Meas. Tech.
n-Vitro Fluorescence Assay for Identification of Renin-Inhibitory Activity
IC50
>30000±n/a nM
Citation
 Klein, M Hydroxy-ethylene derivatives for the treatment of arthrosis US Patent  US10202418 Publication Date 2/12/2019 
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
  
Inhibitor
Name:
BDBM347298
Synonyms:
US10202418, Compound A10
Type:
Small organic molecule
Emp. Form.:
C35H45N3O5
Mol. Mass.:
587.7489
SMILES:
CC(C)[C@H](NC(=O)COc1ccc(C)c(C)c1)C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CCC(=O)NCCc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: