Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM300812
Substrate
n/a
Meas. Tech.
Calcium Flux Assay
EC50
41.0±n/a nM
Citation
 Huang, H; Kuo, G; Player, MR; Yang, S; Zhang, Y Substituted benzothiophenyl derivatives as GPR40 agonists for the treatment of type II diabetes US Patent  US9790198 Publication Date 10/17/2017 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM300812
Synonyms:
(3S)-3-[4-[[3-(2,6- Dimethylphenyl)benzo[b]thiophen- 5-yl]methoxy]phenyl] hex-4-ynoic acid | US10131648, Compound 10 | US10195178, Compound 10 | US9790198, Compound 10
Type:
Small organic molecule
Emp. Form.:
C29H26O3S
Mol. Mass.:
454.58
SMILES:
CC#C[C@@H](CC(O)=O)c1ccc(OCc2ccc3scc(-c4c(C)cccc4C)c3c2)cc1 |r,wD:3.7,(6.51,-4.86,;6.11,-3.38,;5.71,-1.89,;5.31,-.4,;6.4,.69,;7.89,.29,;8.98,1.38,;8.29,-1.2,;3.82,-0,;2.73,-1.09,;1.25,-.69,;.85,.79,;-.64,1.19,;-1.04,2.68,;-2.53,3.08,;-3,4.54,;-4.51,4.86,;-5.54,3.72,;-7.08,3.72,;-7.55,2.25,;-6.31,1.35,;-6.31,-.19,;-4.97,-.96,;-3.64,-.19,;-4.97,-2.5,;-6.31,-3.27,;-7.64,-2.5,;-7.64,-.96,;-8.98,-.19,;-5.06,2.25,;-3.56,1.93,;1.94,1.88,;3.42,1.48,)|
Structure:
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