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Target
Mitogen-activated protein kinase 14
Ligand
BDBM15452
Substrate
biotinylated GST-ATF2
Meas. Tech.
Enzyme Inhibition Assay
IC50
>1000±n/a nM
Citation
 Dombroski, MA; Letavic, MA; McClure, KF; Barberia, JT; Carty, TJ; Cortina, SR; Csiki, C; Dipesa, AJ; Elliott, NC; Gabel, CA; Jordan, CK; Labasi, JM; Martin, WH; Peese, KM; Stock, IA; Svensson, L; Sweeney, FJ; Yu, CH Benzimidazolone p38 inhibitors. Bioorg Med Chem Lett 14:919-23 (2004) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM15452
Synonyms:
1,3-diethyl-5-[5-(4-fluoro-3-methylphenyl)-1H-1,2,3,4-tetrazol-1-yl]-2,3-dihydro-1H-1,3-benzodiazol-2-one | benzimidazolone 20
Type:
Small organic molecule
Emp. Form.:
C19H19FN6O
Mol. Mass.:
366.3922
SMILES:
CCn1c2ccc(cc2n(CC)c1=O)-n1nnnc1-c1ccc(F)c(C)c1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
biotinylated GST-ATF2
Synonyms:
ATF-2-GST | ATF2 | Activating transcription factor 2 | Activating transcription factor 2-GST fusion | GST-ATF2 | biotinylated ATF2 substrate | biotinylated activating transcription factor 2
Type:
Other Protein Type
Mol. Mass.:
12237.77
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
109
Sequence:
MSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPS