Reaction Details Report a problem with these data
Target
G-protein coupled estrogen receptor 1
Ligand
BDBM349624
Substrate
n/a
Meas. Tech.
Estrogen Receptor (ER) Degradation Assay
IC50
<1000±n/a nM
Citation
 Strum, JC Benzothiophene estrogen receptor modulators US Patent  US10208011 Publication Date 2/19/2019 
Target
Name:
G-protein coupled estrogen receptor 1
Synonyms:
CEPR | CMKRL2 | DRY12 | G-protein coupled estrogen receptor 1 | G-protein-coupled receptor (GPR30 ) | GPER | GPER1 | GPER1_HUMAN | GPR30
Type:
PROTEIN
Mol. Mass.:
42259.21
Organism:
Homo sapiens (Human)
Description:
ChEMBL_982507
Residue:
375
Sequence:
MDVTSQARGVGLEMYPGTAQPAAPNTTSPELNLSHPLLGTALANGTGELSEHQQYVIGLFLSCLYTIFLFPIGFVGNILILVVNISFREKMTIPDLYFINLAVADLILVADSLIEVFNLHERYYDIAVLCTFMSLFLQVNMYSSVFFLTWMSFDRYIALARAMRCSLFRTKHHARLSCGLIWMASVSATLVPFTAVHLQHTDEACFCFADVREVQWLEVTLGFIVPFAIIGLCYSLIVRVLVRAHRHRGLRPRRQKALRMILAVVLVFFVCWLPENVFISVHLLQRTQPGAAPCKQSFRHAHPLTGHIVNLAAFSNSCLNPLIYSFLGETFRDKLRLYIEQKTNLPALNRFCHAALKAVIPDSTEQSDVRFSSAV
  
Inhibitor
Name:
BDBM349624
Synonyms:
(S)-(4-fluoro-2,6-dimethylphenyl)(6- hydroxy-3-(4-(2-(3-methylpyrrolidin-1- yl)ethyl)phenoxy)benzo[b]thiophen-2- yl)methanone | US10208011, Compound 118 | US10981887, Compound 118
Type:
Small organic molecule
Emp. Form.:
C30H30FNO3S
Mol. Mass.:
503.628
SMILES:
C[C@H]1CCN(CCc2ccc(Oc3c(sc4cc(O)ccc34)C(=O)c3c(C)cc(F)cc3C)cc2)C1 |r|
Structure:
Search PDB for entries with ligand similarity: