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Target
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Ligand
BDBM350893
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
4560±n/a nM
Citation
 Martinez Gil, A; Gil Ayuso-Gontan, CB; Perez Fernandez, DI; Garcia Fernandez, AM S-substituted quinazolines and their therapeutic applications for the treatment of diseases mediated by PDE7 US Patent  US9796687 Publication Date 10/24/2017 
Target
Name:
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Synonyms:
3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1)
Type:
Enzyme
Mol. Mass.:
55514.96
Organism:
Homo sapiens (Human)
Description:
Q13946
Residue:
482
Sequence:
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
  
Inhibitor
Name:
BDBM350893
Synonyms:
2-Cyclopropylmethylthio-3-(2,6-difluorophenyl)-8-methyl-4-oxo-3,4-dihydroquinazoline | US9796687, Compound 15
Type:
Small organic molecule
Emp. Form.:
C19H16F2N2OS
Mol. Mass.:
358.405
SMILES:
Cc1cccc2c1nc(SCC1CC1)n(-c1c(F)cccc1F)c2=O |(5.33,1.54,;5.33,,;6.67,-.77,;6.67,-2.31,;5.33,-3.08,;4,-2.31,;4,-.77,;2.67,,;1.33,-.77,;;,1.54,;1.33,2.31,;2.1,3.64,;2.87,2.31,;1.33,-2.31,;,-3.08,;-1.33,-2.31,;-1.33,-.77,;-2.67,-3.08,;-2.67,-4.62,;-1.33,-5.39,;,-4.62,;1.33,-5.39,;2.67,-3.08,;2.67,-4.62,)|
Structure:
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