Reaction Details Report a problem with these data
Target
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Ligand
BDBM350902
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
540±n/a nM
Citation
 Martinez Gil, A; Gil Ayuso-Gontan, CB; Perez Fernandez, DI; Garcia Fernandez, AM S-substituted quinazolines and their therapeutic applications for the treatment of diseases mediated by PDE7 US Patent  US9796687 Publication Date 10/24/2017 
Target
Name:
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Synonyms:
3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1)
Type:
Enzyme
Mol. Mass.:
55514.96
Organism:
Homo sapiens (Human)
Description:
Q13946
Residue:
482
Sequence:
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
  
Inhibitor
Name:
BDBM350902
Synonyms:
8-Chloro-2-(3-pyridylmethylthio)-4-oxo-3,4-dihydroquinazoline | US9796687, Compound 25
Type:
Small organic molecule
Emp. Form.:
C14H10ClN3OS
Mol. Mass.:
303.767
SMILES:
Clc1cccc2c1nc(SCc1cccnc1)[nH]c2=O
Structure:
Search PDB for entries with ligand similarity: