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Target
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Ligand
BDBM350906
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
90.0±n/a nM
Citation
 Martinez Gil, A; Gil Ayuso-Gontan, CB; Perez Fernandez, DI; Garcia Fernandez, AM S-substituted quinazolines and their therapeutic applications for the treatment of diseases mediated by PDE7 US Patent  US9796687 Publication Date 10/24/2017 
Target
Name:
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Synonyms:
3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1)
Type:
Enzyme
Mol. Mass.:
55514.96
Organism:
Homo sapiens (Human)
Description:
Q13946
Residue:
482
Sequence:
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTALYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRSSRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPWDILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFSHLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKCADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYLVEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENRLS
  
Inhibitor
Name:
BDBM350906
Synonyms:
3-Phenyl-2-(2-naphthylmethylthio)-4-oxo-3,4-dihydroquinazoline | US9796687, Compound 28
Type:
Small organic molecule
Emp. Form.:
C25H18N2OS
Mol. Mass.:
394.488
SMILES:
O=c1n(c(SCc2ccc3ccccc3c2)nc2ccccc12)-c1ccccc1
Structure:
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