Reaction Details Report a problem with these data
Target
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Ligand
BDBM354479
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
55±n/a nM
Citation
 Desroy, N; Heckmann, B; Brys, RC; Joncour, AM; Peixoto, C; Bock, XM; Housseman, CG Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders US Patent  US9796719 Publication Date 10/24/2017 
Target
Name:
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2
Synonyms:
Autotaxin | Autotaxin (mATX) | ENPP2_MOUSE | Ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2) | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | Enpp2 | Npps2 | Pdnp2
Type:
PROTEIN
Mol. Mass.:
98896.47
Organism:
Mus musculus
Description:
n/a
Residue:
862
Sequence:
MARQGCFGSYQVISLFTFAIGVNLCLGFTASRIKRAEWDEGPPTVLSDSPWTNTSGSCKGRCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLSRGDCCTNYQVVCKGESHWVDDDCEEIRVPECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDATFHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLKLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRPKIPNNLKYDPKAIIANLTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDLHLLVERRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTLPEEVSRPNYPGIMYLQSDFDLGCTCDDKVEPKNKLEELNKRLHTKGSTEERHLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWTYFQRVLVKKYASERNGVNVISGPIFDYNYNGLRDIEDEIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCNSSEDESKWVEELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYESEI
  
Inhibitor
Name:
BDBM354479
Synonyms:
N-(2-ethyl-6-(3- morpholino- pyrrolidin-1- yl)imidazo[1,2- b]pyridazin-3-yl)-4- (4-fluorophenyl)-N- methylthiazol-2- amine | US9796719, Compound 147
Type:
Small organic molecule
Emp. Form.:
C26H30FN7OS
Mol. Mass.:
507.626
SMILES:
CCc1nc2ccc(nn2c1N(C)c1nc(cs1)-c1ccc(F)cc1)N1CCC(C1)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: