Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM352020
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Vechorkin, O; Li, Y; Zhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent  US9802918 Publication Date 10/31/2017 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM352020
Synonyms:
(3R,4R,5S)-3-Amino-1-{3-[({6-[2,6-difluoro-4-(3-hydroxytetrahydrofuran-3-yl)phenyl]-5-fluoropyridin-2-yl}methyl)amino]pyridin-4-yl}-5-methylpiperidin-4-ol | US9802918, Example 1
Type:
Small organic molecule
Emp. Form.:
C27H30F3N5O3
Mol. Mass.:
529.554
SMILES:
C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCOC1 |r,wU:5.5,1.0,wD:7.8,(-.67,.74,;-2,-.03,;-2,-1.57,;-3.33,-2.34,;-4.67,-1.57,;-4.67,-.03,;-6,.74,;-3.33,.74,;-3.33,2.28,;-3.33,-3.88,;-4.67,-4.65,;-4.67,-6.19,;-3.33,-6.96,;-2,-6.19,;-2,-4.65,;-.67,-3.88,;.67,-4.65,;2,-3.88,;3.33,-4.65,;4.67,-3.88,;4.67,-2.34,;6,-1.57,;3.33,-1.57,;2,-2.34,;3.33,-.03,;2,.74,;.67,-.03,;2,2.28,;3.33,3.05,;4.67,2.28,;4.67,.74,;6,-.03,;3.33,4.59,;4.67,3.82,;2.09,5.5,;2.56,6.96,;4.1,6.96,;4.58,5.5,)|
Structure:
Search PDB for entries with ligand similarity: