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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM352077
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Vechorkin, O; Li, Y; Zhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent  US9802918 Publication Date 10/31/2017 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM352077
Synonyms:
(3R,4R,5S)-3-Amino-1-(3-(((6-(2,6-difluoro-3-(1-hydroxycyclopropyl)phenyl)-5-fluoropyridin-2-yl)methyl)amino)pyridin-4-yl)-5-methylpiperidin-4-ol | US9802918, Example 9
Type:
Small organic molecule
Emp. Form.:
C26H28F3N5O2
Mol. Mass.:
499.528
SMILES:
C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)ccc(c1F)C1(O)CC1 |r,wU:1.0,5.5,wD:7.8,(-1.33,2.03,;-2.67,1.26,;-2.67,-.28,;-4,-1.05,;-5.33,-.28,;-5.33,1.26,;-6.67,2.03,;-4,2.03,;-4,3.57,;-4,-2.59,;-5.33,-3.36,;-5.33,-4.9,;-4,-5.67,;-2.67,-4.9,;-2.67,-3.36,;-1.33,-2.59,;,-3.36,;1.33,-2.59,;2.67,-3.36,;4,-2.59,;4,-1.05,;5.33,-.28,;2.67,-.28,;1.33,-1.05,;2.67,1.26,;1.33,2.03,;,1.26,;1.33,3.57,;2.67,4.34,;4,3.57,;4,2.03,;5.33,1.26,;5.33,4.34,;6.67,3.57,;6.1,5.67,;4.56,5.67,)|
Structure:
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