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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM352080
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Vechorkin, O; Li, Y; Zhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent  US9802918 Publication Date 10/31/2017 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM352080
Synonyms:
(3R,4R,5S)-3-Amino-1-{3-[({6-[2,6-difluoro-4-(2-hydroxy-2-methylpropyl)phenyl]-5-fluoropyridin-2-yl}methyl)amino]pyridin-4-yl}-5-methylpiperidin-4-ol | US9802918, Example 12
Type:
Small organic molecule
Emp. Form.:
C27H32F3N5O2
Mol. Mass.:
515.5705
SMILES:
C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CC(C)(C)O)cc1F |r,wU:5.5,1.0,wD:7.8,(-.67,.77,;-2,,;-2,-1.54,;-3.33,-2.31,;-4.67,-1.54,;-4.67,,;-6,.77,;-3.33,.77,;-3.33,2.31,;-3.33,-3.85,;-4.67,-4.62,;-4.67,-6.16,;-3.33,-6.93,;-2,-6.16,;-2,-4.62,;-.67,-3.85,;.67,-4.62,;2,-3.85,;3.33,-4.62,;4.67,-3.85,;4.67,-2.31,;6,-1.54,;3.33,-1.54,;2,-2.31,;3.33,,;2,.77,;.67,,;2,2.31,;3.33,3.08,;3.33,4.62,;2,5.39,;.67,4.62,;2,6.93,;3.33,6.16,;4.67,2.31,;4.67,.77,;6,,)|
Structure:
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