Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM352083
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Vechorkin, O; Li, Y; Zhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent  US9802918 Publication Date 10/31/2017 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM352083
Synonyms:
(3R,4R,5S)-3-Amino-1-(3-(((5-fluoro-6-(2-fluoro-6-methoxyphenyl)pyridin-2-yl)methyl)amino)pyridin-4-yl)-5-methylpiperidin-4-ol | US9802918, Example 15
Type:
Small organic molecule
Emp. Form.:
C24H27F2N5O2
Mol. Mass.:
455.5003
SMILES:
COc1cccc(F)c1-c1nc(CNc2cnccc2N2C[C@H](C)[C@@H](O)[C@H](N)C2)ccc1F |r,wU:26.28,22.24,wD:24.26,(6.72,2.67,;5.38,1.9,;4.05,2.67,;4,4.23,;2.67,5,;1.33,4.23,;1.33,2.69,;,1.93,;2.67,1.92,;2.67,.38,;1.33,-.38,;1.33,-1.92,;,-2.69,;-1.33,-1.92,;-2.67,-2.7,;-2.67,-4.23,;-4,-5,;-5.33,-4.23,;-5.33,-2.7,;-4,-1.93,;-4,-.39,;-2.67,.38,;-2.67,1.92,;-1.33,2.69,;-4,2.69,;-4,4.23,;-5.33,1.92,;-6.67,2.69,;-5.33,.38,;2.67,-2.69,;4,-1.92,;4,-.38,;5.33,.39,)|
Structure:
Search PDB for entries with ligand similarity: